Modern microscopes easily produce large data volumes (terabyte datasets) at high rate (1,000 megabytes/s is no exception) that makes using them almost impossible. Once an acquisition is started, it typically has to be stopped again as the hard drives run full. We'll share how GPUs helped us bring this nightmare to an end. We'll introduce our open-source package, called sqeazy, that is capable of compressing microscopic data at faster speeds than a hard drive can spin. We show how GPUs provided a crucial boost in this endeavor and we'll share what technical challenges we overcame interfacing with modern video encoding libraries, like libavcodec of ffmpeg. Finally, we'll discuss how NVENC provides portable performance that helps scientists to observe living developing specimens over long time spans. This may be the foundation for modern predictive biology of the 21st century. Join us for a tour on how modern media technology straight from Hollywood can boost science!