Estimating the evolutionary history of organisms, phylogenetic inference, is a critical step in many analyses involving biological sequence data such as DNA. These phylogenetic relationships are essential in understanding the evolutionary dynamics of organisms. The likelihood calculations at the heart of the most effective methods for phylogenetic analyses are extremely computationally intensive, and hence these analyses become a bottleneck in many studies. In collaboration with some of the foremost researchers in our area, we have developed an open source library, BEAGLE, which uses GPUs to greatly accelerate phylogenetic analyses. BEAGLE is used by some of the leading programs in the field. We'll describe the phylogenetic inference problem and its importance, and go into details on how we used GPU computing to achieve broad impact in the field.